Treatment options for men are similar to those for women, including the use of antidepressant medication, psychotherapy, or a combination of both. Several pharmacologic agents have evidence of efficacy, including selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors, tricyclics, and monoamine oxidase inhibitors. However, it is important to keep in mind that some antidepressant medications, particularly SSRIs, may lead to sexual dysfunction.
Several forms of short-term, time-limited psychotherapy, including psychodynamic psychotherapy, cognitive behavioral therapy, and interpersonal therapy, have been demonstrated to be effective for treating depression. All-male group therapy has been found to provide men with a safe environment to discover and express intense and vulnerable emotions associated with their depression and allow them to connect through a shared experience. It is important to consider the patient’s preference for treatment, as studies have found that this can significantly influence outcomes.